GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP Research Proposal

GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP LEVEL in the diagnosis of Heart failure - Research Proposal Example To help establish the outcomes, the study will be embedded on extracting DNA samples from 80 patients undergoing elective cardiac catheterization and analyzing with exclusion done on patients with elevated troponin. This will be driven by a detailed data collection including laboratory, standard demographic, catheterization and echocardiographic data. The Genotype will be evaluated at 19 loci on five BNP’s pathway relevant genes (Knowles, Erickson, Guy et al, 2003). To access the incremental influence of the genetic variants, the researcher will employ the Multivariate linear regression of logBNP model adjusted for clinical variables. The proposal will thus try to help properly incorporate the use of NPs to improve the levels of accuracy with respect to decisions made in an emergency setting to curb the missed incidence of diagnostic failures for HF. This will be measured by reduced cases of fatigue, dyspnea, and fluid retention that are all predisposing factors to HF based on cardiac dysfunction hence presenting difficulties in diagnosing HF. The missed incidence are hence strongly correlate to highly significant mortality increases, presenting the need for designing effective diagnostic tools with higher degrees of specification and sensitivity that if employed, can help weed out the increased cases of HF missed diagnose s and particularly, in the busy Heart failure is characterized by its typical but non-specific symptoms like fatigue, dyspnea and fluid retention caused by dysfunction of cardiac which present daunting challenges for diagnosis of HF culminating into increased missed incidence hence higher mortality rates. For this reason, the topic has captured the attention of various researchers to help design effective mechanism and approaches that can be used during diagnosis to detect this catastrophic cardiovascular disease quickly and accurately. For instance, to gauge the potentiality of NPs in augmenting the clinical judgment and/or standard